Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
Identifieur interne : 002803 ( Ncbi/Merge ); précédent : 002802; suivant : 002804Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?
Auteurs : Bingwen Liu [République populaire de Chine] ; Min Li [République populaire de Chine] ; Zhiguang Zhou [République populaire de Chine] ; Xuan Guan [États-Unis] ; Yufei Xiang [République populaire de Chine]Source :
- Journal of autoimmunity [ 1095-9157 ] ; 2020.
Abstract
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are among the leading causes of death in critically ill patients with COVID-19. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome (CRS), may play a major role in the pathology of COVID-19. However, the efficacy of corticosteroids, commonly utilized antiinflammatory agents, to treat COVID-19-induced CRS is controversial. There is an urgent need for novel therapies to treat COVID-19-induced CRS. Here, we discuss the pathogenesis of severe acute respiratory syndrome (SARS)-induced CRS, compare the CRS in COVID-19 with that in SARS and Middle East respiratory syndrome (MERS), and summarize the existing therapies for CRS. We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application.
DOI: 10.1016/j.jaut.2020.102452
PubMed: 32291137
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Electronic address: xuan.guan.md@adventhealth.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, AdventHealth Orlando, Orlando</wicri:regionArea><wicri:noRegion>Orlando</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yufei" sort="Xiang, Yufei" uniqKey="Xiang Y" first="Yufei" last="Xiang">Yufei Xiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China. Electronic address: yufei.xiang@csu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan</wicri:regionArea><wicri:noRegion>Hunan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of autoimmunity</title><idno type="eISSN">1095-9157</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are among the leading causes of death in critically ill patients with COVID-19. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome (CRS), may play a major role in the pathology of COVID-19. However, the efficacy of corticosteroids, commonly utilized antiinflammatory agents, to treat COVID-19-induced CRS is controversial. There is an urgent need for novel therapies to treat COVID-19-induced CRS. Here, we discuss the pathogenesis of severe acute respiratory syndrome (SARS)-induced CRS, compare the CRS in COVID-19 with that in SARS and Middle East respiratory syndrome (MERS), and summarize the existing therapies for CRS. We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32291137</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9157</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>10</Day></PubDate></JournalIssue><Title>Journal of autoimmunity</Title><ISOAbbreviation>J. Autoimmun.</ISOAbbreviation></Journal><ArticleTitle>Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?</ArticleTitle><Pagination><MedlinePgn>102452</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0896-8411(20)30067-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaut.2020.102452</ELocationID><Abstract><AbstractText>The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are among the leading causes of death in critically ill patients with COVID-19. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome (CRS), may play a major role in the pathology of COVID-19. However, the efficacy of corticosteroids, commonly utilized antiinflammatory agents, to treat COVID-19-induced CRS is controversial. There is an urgent need for novel therapies to treat COVID-19-induced CRS. Here, we discuss the pathogenesis of severe acute respiratory syndrome (SARS)-induced CRS, compare the CRS in COVID-19 with that in SARS and Middle East respiratory syndrome (MERS), and summarize the existing therapies for CRS. We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Bingwen</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China; Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Zhiguang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guan</LastName><ForeName>Xuan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, AdventHealth Orlando, Orlando, USA. Electronic address: xuan.guan.md@adventhealth.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Yufei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha, Hunan, China. Electronic address: yufei.xiang@csu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Autoimmun</MedlineTA><NlmUniqueID>8812164</NlmUniqueID><ISSNLinking>0896-8411</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coronavirus disease 2019</Keyword><Keyword MajorTopicYN="N">Cytokine release syndrome</Keyword><Keyword MajorTopicYN="N">Interleukin-6</Keyword><Keyword MajorTopicYN="N">Tocilizumab</Keyword></KeywordList><CoiStatement>Declaration of competing interest No potential conflicts of interest relevant to this review were 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IdType="pmc">PMC7151347</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Oral Oncol. 2020 Mar 21;:104659</Citation><ArticleIdList><ArticleId IdType="pubmed">32209313</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Reprod Immunol. 2018 Apr;126:60-68</Citation><ArticleIdList><ArticleId IdType="pubmed">29524791</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Respirology. 2006 Nov;11(6):715-22</Citation><ArticleIdList><ArticleId IdType="pubmed">17052299</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2014 Jan;88(2):913-24</Citation><ArticleIdList><ArticleId IdType="pubmed">24198408</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Clin Oncol. 2018 Apr;15(4):234-248</Citation><ArticleIdList><ArticleId IdType="pubmed">29405201</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pediatr Emerg Care. 2009 Sep;25(9):599-602</Citation><ArticleIdList><ArticleId IdType="pubmed">19755901</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pharmazie. 2016 Nov 2;71(11):636-639</Citation><ArticleIdList><ArticleId IdType="pubmed">29441967</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biol Blood Marrow Transplant. 2016 May;22(5):862-8</Citation><ArticleIdList><ArticleId IdType="pubmed">26551636</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2010 Sep;84(18):9318-25</Citation><ArticleIdList><ArticleId IdType="pubmed">20610717</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>BMJ. 2003 Jun 21;326(7403):1358-62</Citation><ArticleIdList><ArticleId IdType="pubmed">12816821</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nature. 2020 Mar;579(7798):270-273</Citation><ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Rheumatol. 2012 Apr;18(3):134-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22426581</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15657466</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Blood. 2014 Jul 10;124(2):188-95</Citation><ArticleIdList><ArticleId IdType="pubmed">24876563</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Br J Haematol. 2013 Aug;162(3):376-82</Citation><ArticleIdList><ArticleId IdType="pubmed">23692048</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Virol. 2005 Feb;75(2):185-94</Citation><ArticleIdList><ArticleId IdType="pubmed">15602737</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Host Microbe. 2016 Feb 10;19(2):181-93</Citation><ArticleIdList><ArticleId IdType="pubmed">26867177</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Thorax. 2011 May;66(5):368-74</Citation><ArticleIdList><ArticleId IdType="pubmed">21310755</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Transplantation. 2010 Oct 27;90(8):825-35</Citation><ArticleIdList><ArticleId IdType="pubmed">20697326</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Acta Haematol. 2012;128(2):69-72</Citation><ArticleIdList><ArticleId IdType="pubmed">22678422</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Blood. 2013 Aug 22;122(8):1510-7</Citation><ArticleIdList><ArticleId IdType="pubmed">23861248</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17;41(2):145-151</Citation><ArticleIdList><ArticleId IdType="pubmed">32064853</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Med. 2018 Jun;24(6):731-738</Citation><ArticleIdList><ArticleId IdType="pubmed">29808005</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2003 May 24;361(9371):1767-72</Citation><ArticleIdList><ArticleId IdType="pubmed">12781535</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biochem Pharmacol. 2013 Aug 1;86(3):410-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23707973</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cytokine. 2018 Apr;104:8-13</Citation><ArticleIdList><ArticleId IdType="pubmed">29414327</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virol J. 2019 May 27;16(1):69</Citation><ArticleIdList><ArticleId IdType="pubmed">31133031</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Front Immunol. 2019 Jun 21;10:1393</Citation><ArticleIdList><ArticleId IdType="pubmed">31293574</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Pediatrics. 2007 Sep;120(3):e622-8</Citation><ArticleIdList><ArticleId IdType="pubmed">17698967</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Immunother Cancer. 2018 Jun 15;6(1):56</Citation><ArticleIdList><ArticleId IdType="pubmed">29907163</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Rheumatology (Oxford). 2011 Feb;50(2):417-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20693540</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Med. 2007 Oct;13(10):1248-52</Citation><ArticleIdList><ArticleId IdType="pubmed">17891146</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Infect Immun. 2004 Aug;72(8):4410-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15271897</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Int J Antimicrob Agents. 2020 Mar 20;:105949</Citation><ArticleIdList><ArticleId IdType="pubmed">32205204</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell. 2011 Sep 16;146(6):980-91</Citation><ArticleIdList><ArticleId IdType="pubmed">21925319</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Ther Apher Dial. 2015 Apr;19(2):178-84</Citation><ArticleIdList><ArticleId IdType="pubmed">25363618</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Mol Immunol. 2015 Nov;12(6):681-91</Citation><ArticleIdList><ArticleId IdType="pubmed">25088224</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Invest Dermatol. 2014 Apr;134(4):992-1000</Citation><ArticleIdList><ArticleId IdType="pubmed">24213371</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Immunotherapy. 2016 Jul;8(8):959-70</Citation><ArticleIdList><ArticleId IdType="pubmed">27381687</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Thorax. 2017 Nov;72(11):971-980</Citation><ArticleIdList><ArticleId IdType="pubmed">28082531</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Respir Res. 2014 Apr 04;15:39</Citation><ArticleIdList><ArticleId IdType="pubmed">24708472</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Drugs. 2019 Jan;79(1):99-103</Citation><ArticleIdList><ArticleId IdType="pubmed">30623346</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biol Blood Marrow Transplant. 2017 Sep;23(9):1478-1484</Citation><ArticleIdList><ArticleId IdType="pubmed">28495641</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Immunol. 2017 Apr;37(3):273-276</Citation><ArticleIdList><ArticleId IdType="pubmed">28265964</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Oncol. 2014 Dec;15(13):1451-1459</Citation><ArticleIdList><ArticleId IdType="pubmed">25456364</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet Respir Med. 2015 Jan;3(1):24-32</Citation><ArticleIdList><ArticleId IdType="pubmed">25529339</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Radiology. 2005 Apr;235(1):168-75</Citation><ArticleIdList><ArticleId IdType="pubmed">15703312</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Blood. 2005 Oct 1;106(7):2366-74</Citation><ArticleIdList><ArticleId IdType="pubmed">15860669</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Semin Immunopathol. 2017 Jul;39(5):529-539</Citation><ArticleIdList><ArticleId IdType="pubmed">28466096</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Shock. 2019 Jul;52(1):83-91</Citation><ArticleIdList><ArticleId IdType="pubmed">30028782</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Autoimmun. 2019 Jun;100:62-74</Citation><ArticleIdList><ArticleId IdType="pubmed">30879886</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2012 Dec 20;367(25):2396-406</Citation><ArticleIdList><ArticleId IdType="pubmed">23252526</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2006 Mar 11;367(9513):870-3</Citation><ArticleIdList><ArticleId IdType="pubmed">16530581</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Gen Virol. 2011 Nov;92(Pt 11):2542-2548</Citation><ArticleIdList><ArticleId IdType="pubmed">21752960</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Allergy Clin Immunol. 2017 May;139(5):1698-1701</Citation><ArticleIdList><ArticleId IdType="pubmed">27876626</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Can J Physiol Pharmacol. 2017 Jul;95(7):866-872</Citation><ArticleIdList><ArticleId IdType="pubmed">28459157</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2012 Dec 20;367(25):2385-95</Citation><ArticleIdList><ArticleId IdType="pubmed">23252525</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Microbiol. 2019 Mar;17(3):181-192</Citation><ArticleIdList><ArticleId IdType="pubmed">30531947</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Mil Med Res. 2020 Feb 6;7(1):4</Citation><ArticleIdList><ArticleId IdType="pubmed">32029004</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2004 Jan 17;363(9404):203-9</Citation><ArticleIdList><ArticleId IdType="pubmed">14738793</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Hematol. 2001 Sep;68(1):4-10</Citation><ArticleIdList><ArticleId IdType="pubmed">11559930</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Hematol. 2006 Jan;81(1):59-61</Citation><ArticleIdList><ArticleId IdType="pubmed">16369976</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Immunol Methods. 2016 Jul;434:1-8</Citation><ArticleIdList><ArticleId IdType="pubmed">27049586</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Rev Clin Oncol. 2018 Jan;15(1):47-62</Citation><ArticleIdList><ArticleId IdType="pubmed">28925994</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Rheumatol. 2015 Jun;42(6):994-1001</Citation><ArticleIdList><ArticleId IdType="pubmed">25877504</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Cell Mol Immunol. 2016 Jan;13(1):3-10</Citation><ArticleIdList><ArticleId IdType="pubmed">26189369</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2020 Feb 15;395(10223):507-513</Citation><ArticleIdList><ArticleId IdType="pubmed">32007143</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Blood. 2017 Dec 21;130(25):2728-2738</Citation><ArticleIdList><ArticleId IdType="pubmed">28935695</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Lancet. 2003 May 24;361(9371):1773-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12781536</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Crit Care Med. 2018 Sep;46(9):1411-1420</Citation><ArticleIdList><ArticleId IdType="pubmed">29979221</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>N Engl J Med. 2013 Apr 18;368(16):1509-1518</Citation><ArticleIdList><ArticleId IdType="pubmed">23527958</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Trends Pharmacol Sci. 2004 Jun;25(6):291-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15165741</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Nat Med. 2018 Jun;24(6):739-748</Citation><ArticleIdList><ArticleId IdType="pubmed">29808007</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Ann Rheum Dis. 2016 Jan;75(1):68-74</Citation><ArticleIdList><ArticleId IdType="pubmed">26056119</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Respir Crit Care Med. 2013 Apr 1;187(7):743-50</Citation><ArticleIdList><ArticleId IdType="pubmed">23348980</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Arthritis Rheum. 2012 Dec;64(12):4135-42</Citation><ArticleIdList><ArticleId IdType="pubmed">22886474</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Eur Rev Med Pharmacol Sci. 2016;20(4):745-50</Citation><ArticleIdList><ArticleId IdType="pubmed">26957279</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Bingwen" sort="Liu, Bingwen" uniqKey="Liu B" first="Bingwen" last="Liu">Bingwen Liu</name></noRegion><name sortKey="Li, Min" sort="Li, Min" uniqKey="Li M" first="Min" last="Li">Min Li</name><name sortKey="Xiang, Yufei" sort="Xiang, Yufei" uniqKey="Xiang Y" first="Yufei" last="Xiang">Yufei Xiang</name><name sortKey="Zhou, Zhiguang" sort="Zhou, Zhiguang" uniqKey="Zhou Z" first="Zhiguang" last="Zhou">Zhiguang Zhou</name></country><country name="États-Unis"><noRegion><name sortKey="Guan, Xuan" sort="Guan, Xuan" uniqKey="Guan X" first="Xuan" last="Guan">Xuan Guan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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